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home / centre for automotive safety research / Publications / List / Details Publication Details| Title | Usefulness of beta 2-transferrin assay in the detection of cerebrospinal fluid leaks following head injury | | Authors | Ryall RG, Peacock MK, Simpson DA | | Year | 1992 | | Type | Journal Article | | Abstract | The clinical value of analyzing various fluids and exudates for Beta2-transferrin to detect cerebrospinal fluid (CSF) leakage following head trauma was reviewed in a series of 1 1 cases. Qualitative detection of Beta2-Tfn was performed by agarose gel electrophoresis of tears, ear and nose exudates, cerebral cyst fluid, and wound discharge fluid in different cases. In each instance the presence of Beta2-Tfn in the analyzed fluid supported the diagnosis of a CSF leak. Equally, the demonstration of the absence of Beta2-Tfn in the fluid excluded the diagnosis of such a leak. Neither false-positive nor false-negative results were found, as indicated by separate radiological investigations and/or subsequent clinical assessment of patients. The detection of Beta2-Tfn in suspect fluids thus provides a highly sensitive and selective, rapid, and noninvasive test for the detection of CSF leakage in cases of head trauma. | | Journal Title | Journal of Neurosurgery | | Journal Volume (Issue) | 77(5) | | Page Range | 737-739 | | Page Count | 4 | | Notes | available from CASR library on request |
| Reference | | Ryall RG, Peacock MK, Simpson DA (1992). Usefulness of beta 2-transferrin assay in the detection of cerebrospinal fluid leaks following head injury. Journal of Neurosurgery, 77(5), 737-739. |
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