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Publication Details

TitleUsefulness of beta 2-transferrin assay in the detection of cerebrospinal fluid leaks following head injury
AuthorsRyall RG, Peacock MK, Simpson DA
Year1992
TypeJournal Article
AbstractThe clinical value of analyzing various fluids and exudates for Beta2-transferrin to detect cerebrospinal fluid (CSF) leakage following head trauma was reviewed in a series of 1 1 cases. Qualitative detection of Beta2-Tfn was performed by agarose gel electrophoresis of tears, ear and nose exudates, cerebral cyst fluid, and wound discharge fluid in different cases. In each instance the presence of Beta2-Tfn in the analyzed fluid supported the diagnosis of a CSF leak. Equally, the demonstration of the absence of Beta2-Tfn in the fluid excluded the diagnosis of such a leak. Neither false-positive nor false-negative results were found, as indicated by separate radiological investigations and/or subsequent clinical assessment of patients. The detection of Beta2-Tfn in suspect fluids thus provides a highly sensitive and selective, rapid, and noninvasive test for the detection of CSF leakage in cases of head trauma.
Journal TitleJournal of Neurosurgery
Journal Volume (Issue)77(5)
Page Range737-739
Page Count4
Notesavailable from CASR library on request

Reference
Ryall RG, Peacock MK, Simpson DA (1992) 'Usefulness of beta 2-transferrin assay in the detection of cerebrospinal fluid leaks following head injury', Journal of Neurosurgery, 77(5), pp 737-739.